The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. Highenergy ball milling was used to produce AlxV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ballmilling time was varied from 10 to 100 hours. The ballmilled alloys were consolidated
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The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with low solubility convey a higher risk of failure for drug innovation and development. Pharmacokinetics, pharmacodynamics, and several other ...
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The effects of processing parameters in ball milling and the different behaviors of CuNb and CuMo alloys during milling were investigated. High powder yields can be obtained by changing the BPR value and ball size distribution and no clear dependence of BPR value on powder yield can be found from the experiment results. The addition of oxygen can largely reduce the effect of excessive cold ...
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Hence size reduction technique by a topdown approach using wet milling process was utilized to improve the solubility and, consequently, the dissolution velocity of aceclofenac. The quality of the final product was ensured by Quality by Design approach wherein the effects of critical material attributes and critical process parameters were ...
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A total of 10 g of blend compositions with 5 wt.% Cr were subjected to highenergy ball milling for 12 h in stainlesssteel grinding media by a Spex8000 mill. The ball to powder weight ratio was set as 20:1, and the diameter of the milling ball was in the range of 58 mm.
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Ball milling Media milling High pressure homogenization Cryomilling abstract ... enhance processability or solubility especially for drugs with limited aqueous solubility. The mechanisms by which milling enhances drug dissolution and solubility include alterations in the size, specific surface area and shape of the drug particles as well as ...
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The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. Highenergy ball milling was used to produce AlxV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ballmilling time was varied from 10 to 100 hours. The ballmilled alloys were consolidated under uniaxial pressure of 3GPa at room temperature. The solid solubility of V ...
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Nevertheless, to achieve the best results, parameters such as minimum mixing volume in high shear mixing, powder/solvent and ball/powder ratio in wet ballmilling or finding the most suitable viscosity on the extrusion process, are key for a successful processing of the abovementioned techniques.
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The nanostructured TiMgSr (at.% 70:10:20) was synthesized by ball milling process followed by cold compaction and microwave sintering. XRD results after 30 h milling showed crystallite size of ...
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The powders were ball milled in a zirconia (ZrO 2 ) jar ( L), using zirconia balls in an ambient atmosphere; the mechanical milling was performed in a ball mill, model S/1 1000B (Ceramic ...
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Fig. 5 (A) showed that solubility of BCEWP was distinctly higher than that of CEWP, indicating that ballmilling pretreatment glycosylation modification remarkably magnified the solubility of EWP. Previously, free amino acid content results suggested that ballmilling pretreatment improved the degree of glycosylation reaction, suggesting that ...
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The present study focuses on the investigation of the premilling treatment to the microstructure, phase composition, and solubility in Cu (wt%) alloy processed by a highenergy ball ...
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After enriching the proteins in the bran fraction through conditioning, milling and sieving, further concentration was conducted by solvent extraction followed by an optional purification procedure as described in Fig. were solubilized (see Fig. 1 a) by preparing a suspension of quinoa bran and water in a ratio of 1:10 (w:v). The impact of the pHvalue on protein solubility was ...
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These factors include i) milling timerelated parameters (pause time, number of milling cycles and time of each cycle), ii) speed, iii) milling ball size, and iv) solid to solvent ratio. Nanosization by planetary ball mill significantly resulted in enhancing the dissolution rate and bioavailability of different drugs, like clarithromycin 5 and ...
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In the present work, the formulation of nanosuspension of Ginkgo biloba extract (GBE) and the operating parameters of wet ball milling (WBM) was optimized using the BoxBehnken design (BBD) method. The key formulation factors evaluated were GBE concentration, milling speed, milling time, and sodium dodecyl sulfate (SDS) concentration.
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Many related studies provided the BPR as a principal parameter to describe ball milling experiments. However, same BPR values can be obtained either by changing the number, size, or density of balls or changing the powder weight and balls at the same time. ... The calculation of the solubility of Nb was performed based on the lattice change by ...
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Further studies on the effect of ball milling on the crystallinity and the surface state of cellulose were undertaken by the Saito group, which observed variations of these parameters in aqueous conditions and in the presence of sodium and potassium chloride salts. 25 These studies were conducted on microcrystalline cellulose in a tumbling mill ...
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Wet milling using planetary ball mills has been successfully used to produce nanosuspensions for drugs such as indometacin and brinzolamide 45, 58. Based on the principle of planetary ball milling, Juhnke et al. [59] developed a screening media mill equipped with up to 24 milling beakers of individual milling chamber volumes ...
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Comprehensive insight into protein solubility and thermal stability improvements. ... pH, ionic strength, and additives) parameters (Kramer et al., 2012). Denaturation is considered as one of the main phenomena influencing the protein solubility. Based on the available ... Multidimensional swing highenergy nanoballmilling: Whey protein ...
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Mechanochemistry utilizes mechanical forces to activate chemical bonds. It offers environmentally benign routes for both (bio) organic and inorganic syntheses. However, direct comparison of mechanochemistry results is often very challenging. In mechanochemical synthetic protocols, ball mill setup (mechanical design and grinding vessel geometry) in addition to experimental parameters (milling ...
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For milling time, the ball milling process was interrupted at a regular interval of 10 h for powder extraction and characterization, up to a total milling time of 60 h. It is worth noting that a small ball (which weighs ~1 g) is removed at every g of powder extraction to maintain the balltopowder ratio. Materials characterization
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Ball milling is a mechanical technique that is broadly used to grind powders into fine particles [134141]. The reactants are generally broken apart using solvent molecules in the traditional method; but in ball milling, reactants are broken by using mechanical forces. The term mechanochemistry has been introduced very recently [142].
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The effects of additive dosage, type, ball milling parameters on the solubility of IBU in an IBU delivery system were investigated, and a better solid dispersion formula and mechanochemical preparation process were obtained. The experimental conclusions are shown in Table 1.
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This method allows production of homogeneous materials starting from blended elemental powder mixtures produce a nickelbased superalloy. Mechanical alloying (MA) is a solidstate powder processing technique that involves repeated cold welding, fracturing, and rewelding of powder particles in a highenergy ball mill.
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Before initiating cocrystallization, several ball milling process parameters, including milling time, ball size and RPM were optimized to obtain the cocrystals with the highest purity and yield. ... (BREX), with coformers such as succinic acid and catechol was carried out using ball milling to address the poor solubility and dissolution rate of ...
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A material supplier from Belgium would like to produce limestone powder for his custome...
India is rich in various mineral resources and it is an important mineral processing market
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